Research support

We will continue to support and facilitate implementation research to improve access to quality interventions that reduce the burden of infectious diseases on the most vulnerable.

This includes:

Research for delivery and access

Research training for capacity strengthening

Research for decision-making

TDR will support and facilitate country-led implementation research to improve access to quality services among vulnerable groups. We will close the gap between research and health service practice. Our research will be led by the questions raised by stakeholders, such as frontline workers and development partners, and employ a range of methods and disciplines, depending on the challenge at hand. Our work will take into account context and the interaction of people and environment (both biological and socio-economic) to build resilient systems for health.

Embedding systems strengthening in our support for research

“TDR doesn’t just give grants and wait for reports to come back. It is never a one-time transaction. Over the last eight years, TDR has worked closely with our national TB programme to not only produce research results but to empower us as well. We now feel more in control and bolder in doing research with a stronger, sustainable research system in place. We have also benefited enormously from being part of a regional network that allows us to share and exchange experiences with colleagues in other countries.”

 

– Professor Dissou Affolabi, National TB Programme manager, Benin; Executive Secretary of the West and Central African Regional Networks for TB Control (WARN/CARN-TB)

The TDR checklist to identify research priorities

These criteria allow TDR’s portfolio to be responsive to specific country demands and give back the evidence, knowledge and tools – especially to researchers, practitioners and to communities that most need them, thus democratizing research.

 

Potential initiatives should address the following criteria:

Local priority leading to effective solutions: the research question is identified as important to local stakeholders and the expected results can be translated into feasible and cost-effective solutions.

Strengthens research capacity: the research contributes to the development of skills and capacities of individuals and institutions in low- and middle-income countries to design and undertake research.

Addresses a global health challenge: the work addresses epidemics and outbreaks, control and elimination of diseases of poverty, climate change or resistance to treatment or control agents

Applies a multisectoral or One Health lens: the research brings together relevant disciplines and sectors in novel and holistic approaches.

Promotes equity and ethics: the research enhances social, economic and gender equity, reaching the most disadvantaged people, including hard-to-reach, mobile, marginalized and stigmatized groups.

Open science: data are shared and research outputs are made accessible for policy and practice improvements in ways that are fair to those who conducted the work and the communities where the research took place.

Value for money: the initiative balances economy, efficiency and effectiveness to maximize impact and builds on equitable partnerships.

Research for delivery and access

Inform health system practices for effective delivery and equitable access

 

TDR will support research to understand how new tools, strategies and interventions can deliver improved policy and practice and service delivery in ‘real world’ settings, with a focus on scale-up and equity.

Supporting the development of gender-responsive health interventions
TDR is supporting researchers to generate new knowledge on the intersection of sex and gender with other axes of inequality that affect equitable access to health services and health outcomes. Investigators in low- and middle-income countries have played a critical role in piloting and applying new research tools on intersectional gender analysis that are designed to support implementers, health programme managers and decision-makers. Further information can be found in our Intersectional gender research strategy

Research for innovative solutions

Filling the gaps in tools, strategies and interventions

 

TDR will support implementation research that identifies gaps in existing tools, strategies or interventions and facilitates the development or adaptation of innovative solutions. Research will address gaps in treatment, control, elimination and safety monitoring, as well as in surveillance systems and outbreak response. We aim to ensure that low- and middle-income countries benefit from innovative technologies such as the digital tools available in high-income countries.

The School Guppy Project: A multisectoral socially innovative approach to dengue control in Cambodia

In Cambodia, mosquitoes which can carry dengue virus breed in fresh water collected in containers such as large clay jars used for domestic water storage. TDR supported a study that examined interventions including putting mosquito larvae-eating guppy fish in household water containers, trapping adult mosquitoes, removing mosquito breeding sites near homes and providing community education about dengue, particularly to school children. Stakeholders that participated in the project included the National Malaria and Dengue Control Programme, the Ministry of Health and the Ministry of Education. The School Guppy Project exemplifies TDR’s expertise in social science research to enable multisectoral, community-based solutions to improve health.   

Research for decision-making

Providing data for evidence-based decisions on guidelines and policies

 

TDR will support research that facilitates the formulation of new guidelines and policies. We will find pathways for the accelerated translation of research into policies and guidance for practice. TDR-supported research will include:

 

  • Addressing last-mile challenges of disease elimination where integration into primary health services is particularly important to sustain gains;

 

  • Developing systems for the prevention, early detection and containment of antimicrobial resistance;

 

  • Conducting situation analyses and systematic reviews; and

 

  • Maximizing the utilization of data for public health decision-making, including strengthening researchers’ capacity to communicate their findings.
Evidence for guidelines and country policies to eliminate onchocerciasis
In 2018, U.S. regulators approved moxidectin as the first new treatment for onchocerciasis in 20 years. This was the result of two decades of collaboration between TDR, researchers in onchocerciasis endemic and other countries, WHO country offices and the not-for-profit biopharmaceutical company Medicines Development for Global Health. We are currently supporting the generation of data to inform WHO guidelines and country policies on implementation of moxidectin.